Khaled Anatolios is interested in all aspects of the theology of the early Church, with special emphases on the Trinitarian, Christological, and soteriological doctrines of the Greek fathers and Augustine; early Christian biblical exegesis; and the development of theological methodology in Patristic and medieval theology. He has published on a variety of early Christian theologians including Irenaeus, Origen, Athanasius, Augustine, and Gregory of Nyssa. A particular focus of his work is the engagement between early Christian theological reflection and contemporary theological concerns.